Xanthoderma: A clinical review

“Xanthoderma” is a term that describes a yellow to orange macular discoloration of the skin. The cause of this finding ranges from benign to potentially life-threatening disease. To date the literature fails to comprehensively review the various causes and workup of this clinical manifestation. This article discusses the etiopathogenesis of xanthoderma and suggests a novel diagnostic algorithm for the clinician to use in the initial evaluation of this condition.