کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3210187 1587652 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Neural hyperplasia in chondrodermatitis nodularis chronica helicis
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی امراض پوستی
پیش نمایش صفحه اول مقاله
Neural hyperplasia in chondrodermatitis nodularis chronica helicis
چکیده انگلیسی

BackgroundChondrodermatitis nodularis chronica helicis (CNCH) is a common condition characterized by tender nodules of the helix, of uncertain mechanism. The pain is not explained by current physiopathological hypotheses.ObjectiveWe sought to investigate possible nerve hyperplasia in CNCH.MethodsThirty-seven cases of clinically typical CNCH were submitted to conventional microscopy after surgical excision and analyzed with immunohistochemistry using PS100 and neurofilament antibodies. As controls, we investigated 25 tumors of the ear with the same methods.ResultsLarge nerves (>0.1 mm in diameter) were seen in 8 of 37 cases; these were close to the cartilage or at the upper part of the ulceration. Increased numbers of small nerve sections (0.01-0.06 mm in diameter) were seen in 35 of 37 cases, with more than 20 sections per low-power field in 18 cases. Nerve hyperplasia was not observed in tumors of the ear, even in ulcerated cases.LimitationsHypothesis based on morphologic observations.ConclusionsNerve hyperplasia is present in CNCH, but is often masked by intense vascular and inflammatory reactions. This finding may explain the induction of pain by light pressure, whereas ulcerated auricular malignant tumors are generally painless. Certain authors believe that CNCH is an equivalent of prurigo nodularis, which interestingly also shows nerve hyperplasia.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the American Academy of Dermatology - Volume 55, Issue 5, November 2006, Pages 844–848
نویسندگان
, , ,