کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3211512 | 1587639 | 2007 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Vehicle-controlled, double-blind, randomized study of imiquimod 5% cream applied 3 days per week in one or two courses of treatment for actinic keratoses on the head Vehicle-controlled, double-blind, randomized study of imiquimod 5% cream applied 3 days per week in one or two courses of treatment for actinic keratoses on the head](/preview/png/3211512.png)
BackgroundA shorter dosing regimen of imiquimod for the treatment of actinic keratosis may be effective, with long-term clinical benefits.ObjectiveImiquimod in one or two shorter courses of treatment was evaluated.MethodsPatients with actinic keratosis lesions on the head applied imiquimod or vehicle cream 3×/wk for 4 weeks (course 1). Patients with remaining lesions received another course of treatment. Complete and partial clearance rates were evaluated after course 1, after course 2 (overall), and 1 year later.ResultsComplete clearance rates were 26.8% (course 1) and 53.7% (overall). Partial clearance rates were 36.6% (course 1) and 61.0% (overall). One-year follow-up recurrence rates were 39% (imiquimod) and 57% (vehicle).LimitationsBlinded investigators may have been biased toward patients treated with imiquimod identified by treatment site reactions.ConclusionImiquimod 3×/wk in one or two courses of treatment appears to be effective for the treatment of actinic keratoses on the head, providing long-term clinical benefits. Some recurrences do occur, so long-term follow-up is recommended.
Journal: Journal of the American Academy of Dermatology - Volume 57, Issue 2, August 2007, Pages 265–268