کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3211776 | 1587644 | 2007 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Pemphigus vulgaris presenting in a radiation portal Pemphigus vulgaris presenting in a radiation portal](/preview/png/3211776.png)
We report a case of mucocutaneous pemphigus vulgaris in a patient with squamous cell carcinoma of the lung. The cutaneous involvement was limited to the skin within his therapeutic radiation portal. The diagnosis of pemphigus vulgaris was confirmed by histopathology and immunologic studies. Direct immunofluorescence demonstrated IgG and C3 in the intercellular spaces and indirect immunofluorescence was positive on monkey esophagus at a titer of 1:160. Enzyme-linked immunosorbent assay of the patient's serum detected autoantibodies only to desmoglein (Dsg)3, with no reactivity to Dsg1. Immunomapping of perilesional skin from the irradiated field illustrated decreased Dsg1 expression compared with a control sample from an area that was not exposed to radiation. This case provides support for the Dsg compensation hypothesis and may also suggest a mechanism by which irradiation may induce skin lesions.
Journal: Journal of the American Academy of Dermatology - Volume 56, Issue 5, Supplement, May 2007, Pages S82–S85