کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3211955 | 1587658 | 2006 | 16 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: The vulvovaginal gingival syndrome: A severe subgroup of lichen planus with characteristic clinical features and a novel association with the class II HLA DQB1∗0201 allele The vulvovaginal gingival syndrome: A severe subgroup of lichen planus with characteristic clinical features and a novel association with the class II HLA DQB1∗0201 allele](/preview/png/3211955.png)
BackgroundThe vulvovaginal gingival syndrome is an uncommon and severe variant of lichen planus characterized by erosions or desquamation of vulval, vaginal, and gingival mucosae with a predilection for scarring and stricture formation.ObjectiveWe sought to define the clinical, immunopathologic, and human leukocyte antigen findings in a large cohort of patients.MethodsThe clinical presentation and outcome during long-term follow-up were documented in 40 patients. In addition, human leukocyte antigen typing for class II by polymerase chain reaction and sequence-specific primers was performed.ResultsDuring a mean follow-up period of 8.7 (SD ± 6.8) years, long-term sequelae included strictures of the esophagus, lachrymal ducts, and external auditory canal; loss of vulval architecture; vaginal stenosis; and buccal mucosal fibrosis. The DQB1∗0201 allele was present in 80% of patients versus 41.8% of control subjects (P ≤ .0042; relative risk 3.71).ConclusionEarly diagnosis of this distinct subgroup of lichen planus, combined with appropriate therapeutic measures, may help to minimize the significant physical and psychologic morbidity associated with this scarring disorder.
Journal: Journal of the American Academy of Dermatology - Volume 55, Issue 1, July 2006, Pages 98–113