کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3212020 1587663 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Treatment of linear IgA bullous dermatosis of childhood with flucloxacillin
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی امراض پوستی
پیش نمایش صفحه اول مقاله
Treatment of linear IgA bullous dermatosis of childhood with flucloxacillin
چکیده انگلیسی

BackgroundLinear IgA bullous dermatosis of childhood is a rare autoimmune bullous disease that mainly affects preschool-aged children. Dapsone is considered the first-line therapy with prompt response from most patients. However, it may be contraindicated in certain conditions such as glucose-6-phosphate dehydrogenase deficiency.ObjectiveWe sought to assess the efficacy of flucloxacillin in the treatment of linear IgA bullous dermatosis.MethodsThis is an observational study in which all confirmed cases of linear IgA bullous dermatosis (by both histological and immunofluorescence studies) will be treated with flucloxacillin. Flucloxacillin will be continued according to the response or otherwise will be discontinued after 8 weeks in the case of resistance.ResultsWe describe 7 patients with linear IgA bullous dermatosis of childhood treated with flucloxacillin. In 4 cases, it induced complete remission within 3 to 4 months of starting therapy with no relapses. In the other 3 cases, it successfully controlled the disease but with prompt relapse on discontinuation of the treatment.LimitationsThis is a case series study with a small number of patients.ConclusionFlucloxacillin may be considered among the first alternative therapies for linear IgA bullous dermatosis of childhood. Further evaluation of the efficacy and safety of the long-term use is required.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the American Academy of Dermatology - Volume 54, Issue 4, April 2006, Pages 652–656
نویسندگان
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