کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3217035 1203590 2009 15 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Key Role of Macrophages in the Pathogenesis of CD18 Hypomorphic Murine Model of Psoriasis
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی امراض پوستی
پیش نمایش صفحه اول مقاله
Key Role of Macrophages in the Pathogenesis of CD18 Hypomorphic Murine Model of Psoriasis
چکیده انگلیسی

Psoriasis is a chronic skin disorder of unsolved pathogenesis affecting skin in 2–3% of the general population. Research into the pathogenesis of psoriasis has profited from suitable animal models. Previously, we reported on the CD18 hypomorphic (CD18hypo) PL/J mouse model clinically resembling human psoriasis, which is characterized by reduced expression of the common chain of β2-integrins (CD11/CD18) to only 2–16% of wild-type levels. Aside from common clinical and pathophysiological features shared with human psoriasis, the psoriasiform skin disease in CD18hypo PL/J mice also depends on the presence of CD4+ T-cells. This review focuses on the role of activated macrophages in the pathogenesis of CD18hypo T-cell-mediated mouse model of psoriasis, and extends our understanding in unrestrained pathogenic T-cells whose activation may be crucial for the recruitment and activation of macrophages within skin. The findings in the CD18hypo PL/J model are discussed in the context of current literatures of human and other autoimmune disorders.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Investigative Dermatology - Volume 129, Issue 5, May 2009, Pages 1100–1114
نویسندگان
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