کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3218419 1203640 2006 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Low-Energy Helium-Neon Laser Induces Locomotion of the Immature Melanoblasts and Promotes Melanogenesis of the More Differentiated Melanoblasts: Recapitulation of Vitiligo Repigmentation In Vitro
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی امراض پوستی
پیش نمایش صفحه اول مقاله
Low-Energy Helium-Neon Laser Induces Locomotion of the Immature Melanoblasts and Promotes Melanogenesis of the More Differentiated Melanoblasts: Recapitulation of Vitiligo Repigmentation In Vitro
چکیده انگلیسی

Helium-neon laser (He-Ne Laser, 632.8 nm) is a low-energy laser that has therapeutic efficacy on various clinical conditions. Our previous study has demonstrated efficacy of He-Ne laser on vitiligo, a disease characterized by skin depigmentation. To regain skin tone on vitiligo lesions, the process began by the migration of the immature melanoblasts (MBs) to the epidermis, which was followed by their functional development to produce melanin. In this study, we investigated the physiologic effects of He-Ne laser irradiation on two MB cell lines: the immature NCCmelb4 and the more differentiated NCCmelan5. The intricate interactions between MBs with their innate extracelluar matrix, fibronectin, were also addressed. Our results showed that He-Ne laser irradiation enhanced NCCmelb4 mobility via enhanced phosphorylated focal adhesion kinase expression and promoted melanogenesis in NCCmelan5. In addition, He-Ne laser decreased the affinity between NCCmelb4 and fibronectin, whereas the attachment of NCCmelan5 to fibronectin increased. The α5β1 integrin expression on NCCmelb4 cells was enhanced by He-Ne laser. In conclusion, we have demonstrated that He-Ne laser induced different physiologic changes on MBs at different maturation stages and recapitulated the early events during vitiligo repigmentation process brought upon by He-Ne laser in vitro.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Investigative Dermatology - Volume 126, Issue 9, September 2006, Pages 2119–2126
نویسندگان
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