کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3218869 1407139 2015 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Animal Models for Alopecia Areata: What and Where?
ترجمه فارسی عنوان
مدل های حیوانی برای آلوپسی آراتا: چه چیزی و چه کجا؟
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی امراض پوستی
چکیده انگلیسی

Disease is not limited to humans. Rather, humans are but another mammal in a continuum, and as such, often share similar if not identical diseases with other mammalian species. Alopecia areata (AA) is such a disease. Natural disease occurs in humans, nonhuman primates, many domestic animals, and laboratory rodents. However, to be useful as models of human disease, affected animals need to be readily available to the research community, closely resemble the human disease, be easy to work with, and provide reproducible data. To date, the laboratory mouse (most if not all of the C3H substrains) and the Dundee experimental bald rat fit these criteria. Manipulations using full-thickness skin grafts or specific immune cell transfers have improved the models. New mouse models that carry a variety of genetic-based immunodeficiencies can now be used to recapitulate the human immune system and allow for human full-thickness skin grafts onto mice to investigate human-specific mechanistic and therapeutic questions. These models are summarized here including where they can currently be obtained from public access repositories.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Investigative Dermatology Symposium Proceedings - Volume 17, Issue 2, November 2015, Pages 23–26
نویسندگان
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