کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3219019 1204423 2006 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Reactive Oxygen Species and Their Detoxification in Healing Skin Wounds
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی امراض پوستی
پیش نمایش صفحه اول مقاله
Reactive Oxygen Species and Their Detoxification in Healing Skin Wounds
چکیده انگلیسی

Injury to the skin initiates a cascade of events, which finally lead to at least partial reconstruction of the wounded tissue. The wound-healing process has been well described at the histological level, but the underlying molecular mechanisms are still poorly defined. To gain insight into these mechanisms we searched for genes, which are regulated by skin injury. Interestingly, some of the genes that we identified encode cytoprotective proteins, in particular enzymes, which detoxify reactive oxygen species (ROS). Since ROS are produced in high amounts at the wound site as a defense against invading bacteria, the expression of these genes is most likely important for the protection of cells against these toxic molecules. In this review, we summarize the results on the expression of cytoprotective genes in wounded skin, and we discuss their possible roles in the wound-healing process.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Investigative Dermatology Symposium Proceedings - Volume 11, Issue 1, September 2006, Pages 106–111
نویسندگان
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