Effets de la personnalité sur les troubles neurocognitifs

Hypotheses about links between personality and neurocognitive disorders have been proposed, initially in a psychodynamic perspective. More recently, dimensional models such as the five-factor model have been used. Numerous studies have shown that a high level of neuroticism is correlated with an increased risk of Alzheimer's disease. In contrast, a high level of consciousness seems to be protective. Neuroticism may also modulate the clinical expression of neuropathological lesions in Alzheimer's disease. Finally, premorbid personality might have an influence on neuropsychiatric symptoms in dementia. The correlations between neuroticism and dementia might be explained by a dysregulation of the hypothalamic-pituitary-adrenal axis, alongside other factors. But beyond the consideration of neuroticism as a risk factor for the expression of neurocognitive disorders, possessing information about the subject's personality can help to adapt and shape treatment strategies.