کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3355380 1217173 2014 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Follicular helper T cell-mediated mucosal barrier maintenance
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Follicular helper T cell-mediated mucosal barrier maintenance
چکیده انگلیسی


• The intestinal microbiome establishes and is maintained by germinal centers (GCs).
• High-affinity IgA maintains commensals in the gut under steady-state.
• Follicular helper T cells (Tfh) are essential for mucosa-associated GCs.
• Tfh cells exhibit phenotypic plasticity with other CD4 T cells in the gut.

The basic functions of the immune system are protection from pathogens and maintenance of tolerance to self. The maintenance of commensal microbiota at mucosal surfaces adds a layer of complexity to these basic functions. Recent reports suggest follicular helper T cells (Tfh), a CD4+ T cell subset specialized to provide help to B cells undergoing isotype switching and affinity maturation in germinal centers (GC), interact with the microbiota and are essential to maintenance of mucosal barriers. Complicating the issue is ongoing controversy in the field regarding origin of the Tfh subset and its distinction from other effector CD4 T cell phenotypes (Th1/Th17/Treg). This review focuses on the differentiation, phenotypic plasticity, and function of CD4 T cells, with an emphasis on commensal-specific GC responses in the gut.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Immunology Letters - Volume 162, Issue 2, Part A, December 2014, Pages 39–47
نویسندگان
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