کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3358150 | 1217864 | 2013 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Generación de diversidad de los receptores de antÃgeno en linfocitos: validación del «modelo de accesibilidad» en el control de la recombinación V(D)J
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
V(D)J recombination is the assembly of gene segments at the antigen receptor loci in order to generate antigen receptor diversity in T and B lymphocytes. Detailed knowledge of how V(D)J recombination is normally regulated during lymphocyte development is essential to understand the cases of dysregulation of this process that result in leukemic transformation. V(D)J recombination is triggered by action of a specific endonuclease which is exclusively expressed in immature lymphocytes. According to the “accessibility model” proposed more than 25 years ago, DNA cleavage by this endonuclease is very strictly controlled during cell differentiation by regulating its accessibility to chromatin. This review summarizes the advances in the field over the last few years, including the important role of the genomic conformation and position of the antigen receptor loci within the nucleus, as well as those that have recently culminated with the validation of the “accessibility model” to control this process.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: InmunologÃa - Volume 32, Issue 2, AprilâJune 2013, Pages 57-69
Journal: InmunologÃa - Volume 32, Issue 2, AprilâJune 2013, Pages 57-69
نویسندگان
Alberto GarcÃa-Mariscal, Beatriz del Blanco, Cristina Hernández-Munain,