Altered patterns of epigenetic changes in systemic lupus erythematosus and auto-antibody production: Is there a link?

► Epigenetic alterations are important in the pathogenesis of SLE. ► Epigenetic modifications and auto-antibody production may be linked. ► Hypomethylated DNA is immunogenic and recognized by autoantibodies. ► Anti-histone antibodies bind preferentially epigenetic-sensitive hot spots. ► Epigenetically-modified ribonucleoprotein are important target for autoantibodies.