کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3371352 1219121 2006 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Natural history of oral papillomavirus infections in spouses: A prospective Finnish HPV Family Study
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
پیش نمایش صفحه اول مقاله
Natural history of oral papillomavirus infections in spouses: A prospective Finnish HPV Family Study
چکیده انگلیسی

BackgroundThe natural history of genital human papillomavirus infection is well known, but nearly nothing is known about the outcome of oral HPV-infection.Objectives and study designTo study natural history of oral HPV in spouses during the follow-up 331 women (mean 25.5 ± 3.4 years) and 131 men (mean 28.8 ± 5.0 years) were recruited from maternity unit. Scrapings from healthy oral mucosa of spouses at baseline, 2, 6, 12 and 24 months and genital samples were taken for HPV testing. HPV DNA was detected by nested PCR and confirmed by hybridization using a cocktail of 12 high-risk (HR) oligoprobes.ResultsThe detection rate of HR HPVs varied from 15% to 27%. Baseline oral HPV status between the spouses was closely related (odds ratio 4.3; 95% confidence interval 1.6–12.0; P = 0.006). Persistent oral infection in one spouse was a significant risk factor (odds ratio 10.0; 95% confidence interval 1.5–68.7; P = 0.005) for oral HR HPV persistence in the other partner. Cumulative incidence of new HR HPV infections was identical in both spouses, while men seemed to clear their infection more rapidly. In univariate survival analysis, the partner's oral or genital HPV status, oral sex habits or age did not predict clearance or acquisition of oral HR HPV.ConclusionNatural history of HPV infection in oral mucosa mimics that of genital HPV infection. Oral sex had no association to oral HPV infection, but a persistent oral HPV infection of the spouse increased the risk of persistent oral HPV infection 10-fold in the other spouse.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Clinical Virology - Volume 35, Issue 1, January 2006, Pages 89–94
نویسندگان
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