کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3391577 1221061 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The TCR-mediated signaling pathways that control the direction of helper T cell differentiation
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
The TCR-mediated signaling pathways that control the direction of helper T cell differentiation
چکیده انگلیسی

In the periphery, upon antigen recognition by αβTCR, naïve CD4 T cells undergo functional differentiation and acquire the ability to produce a specific set of cytokines. At least four Th cell subsets, i.e., Th1, Th2, Th17 and iTreg cells have so far been identified and the differentiation of each subset is driven by distinct cytokine sets. Antigen recognition by TCR and the activation of the TCR-mediated signaling pathways that follows, however, are most critical for initiating Th cell differentiation. This review focuses on the TCR signal strength and the TCR-mediated signaling pathways that control the differentiation into these four Th cell subsets.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Immunology - Volume 22, Issue 5, October 2010, Pages 303–309
نویسندگان
, ,