کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3415741 | 1224977 | 2007 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Lipoprotein e (P4) of Haemophilus influenzae: role in heme utilization and pathogenesis
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موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Lipoprotein e (P4) of Haemophilus influenzae: role in heme utilization and pathogenesis Lipoprotein e (P4) of Haemophilus influenzae: role in heme utilization and pathogenesis](/preview/png/3415741.png)
چکیده انگلیسی
Lipoprotein e (P4) of Haemophilus influenzae is a phosphomonoesterase, encoded by the hel gene, that has been implicated in the acquisition of heme by this fastidious organism. However, lipoprotein e (P4) is also involved in the utilization of NAD and NMN. Some reports have concluded that the reported heme-related growth defect actually reflects a growth defect for NAD. In the current study, hel insertion mutants were constructed and a role for e (P4) in heme acquisition was demonstrated independent of its role in NAD or NMN acquisition. In addition, a rat model of infection demonstrated a role for e (P4) in the pathogenesis of invasive disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microbes and Infection - Volume 9, Issue 8, July 2007, Pages 932–939
Journal: Microbes and Infection - Volume 9, Issue 8, July 2007, Pages 932–939
نویسندگان
Daniel J. Morton, Ann Smith, Timothy M. VanWagoner, Thomas W. Seale, Paul W. Whitby, Terrence L. Stull,