کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3415814 | 1593658 | 2006 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Interleukin-1 contributes to an effective clearance of Mycobacterium kansasii from the respiratory tract
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Interleukin-1 contributes to an effective clearance of Mycobacterium kansasii from the respiratory tract Interleukin-1 contributes to an effective clearance of Mycobacterium kansasii from the respiratory tract](/preview/png/3415814.png)
چکیده انگلیسی
Mycobacterium kansasii is an emerging pathogen that is able to induce pulmonary disease resembling tuberculosis. To determine the role of interleukin (IL-)1 in lung infection caused by this atypical mycobacterium, IL-1 receptor type 1 knockout (IL-1R1 KO) and normal wild type mice were intranasally infected with M. kansasii. IL-1R1 KO mice demonstrated a reduced antibacterial response in the lungs and an increased dissemination to the liver, which was accompanied by an enhanced pulmonary inflammatory response. These data identify IL-1 as an important component of the innate immune response to lung infection by M. kansasii.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microbes and Infection - Volume 8, Issues 9–10, August 2006, Pages 2409–2413
Journal: Microbes and Infection - Volume 8, Issues 9–10, August 2006, Pages 2409–2413
نویسندگان
Catharina W. Wieland, Sandrine Florquin, Jennie M. Pater, Sebastiaan Weijer, Tom van der Poll,