کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3426378 | 1227328 | 2009 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Prion expression is activated by Adenovirus 5 infection and affects the adenoviral cycle in human cells Prion expression is activated by Adenovirus 5 infection and affects the adenoviral cycle in human cells](/preview/png/3426378.png)
The prion protein is a cell surface glycoprotein whose physiological role remains elusive, while its implication in transmissible spongiform encephalopathies (TSEs) has been demonstrated. Multiple interactions between the prion protein and viruses have been described: viruses can act as co-factors in TSEs and life cycles of different viruses have been found to be controlled by prion modulation.We present data showing that human Adenovirus 5 induces prion expression. Inactivated Adenovirus did not alter prion transcription, while variants encoding for early products did, suggesting that the prion is stimulated by an early adenoviral function. Down-regulation of the prion through RNA interference showed that the prion controls adenovirus replication and expression.These data suggest that the prion protein could play a role in the defense strategy mounted by the host during viral infection, in a cell autonomous manner. These results have implications for the study of the prion protein and of associated TSEs.
Journal: Virology - Volume 385, Issue 2, 15 March 2009, Pages 343–350