کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4177140 1276393 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Prolonged Period of Cortical Plasticity upon Redox Dysregulation in Fast-Spiking Interneurons
ترجمه فارسی عنوان
دوره طولانی پلاستیسیته قشر پس از اختلال ردکس در اینترنورونهای سریع اسپیکینگ
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
چکیده انگلیسی

BackgroundOxidative stress and the specific impairment of perisomatic gamma-aminobutyric acid circuits are hallmarks of the schizophrenic brain and its animal models. Proper maturation of these fast-spiking inhibitory interneurons normally defines critical periods of experience-dependent cortical plasticity.MethodsHere, we linked these processes by genetically inducing a redox dysregulation restricted to such parvalbumin-positive cells and examined the impact on critical period plasticity using the visual system as a model (3–6 mice/group).ResultsOxidative stress was accompanied by a significant loss of perineuronal nets, which normally enwrap mature fast-spiking cells to limit adult plasticity. Accordingly, the neocortex remained plastic even beyond the peak of its natural critical period. These effects were not seen when redox dysregulation was targeted in excitatory principal cells.ConclusionsA cell-specific regulation of redox state thus balances plasticity and stability of cortical networks. Mistimed developmental trajectories of brain plasticity may underlie, in part, the pathophysiology of mental illness. Such prolonged developmental plasticity may, in turn, offer a therapeutic opportunity for cognitive interventions targeting brain plasticity in schizophrenia.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biological Psychiatry - Volume 78, Issue 6, 15 September 2015, Pages 396–402
نویسندگان
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