کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4178823 | 1276516 | 2010 | 8 صفحه PDF | دانلود رایگان |
BackgroundTraumatic experiences in early childhood are associated with increased risk for developing mood and anxiety disorders later in life. Low serotonin1A receptor (5-HT1AR) density during development has been proposed as a trait-like characteristic leading to increased vulnerability of stress-related neuropsychiatric disorders.MethodsTo assess the relationship between early-life stress and alterations in the serotonin system during development, we used positron emission tomography to measure in vivo 5-HT1AR density and apparent dissociation constant (KDapp) in the brain of juvenile Rhesus monkeys exposed to the early-life stress of peer-rearing.ResultsIn general, 5-HT1AR density and KDapp were decreased in peer-reared compared with control mother-reared animals. However, increase in receptor density was found in the dorsomedial prefrontal cortex of peer-reared females.ConclusionsThese findings suggest that exposure to an adverse early-life environment during infancy is associated with long-term alterations in the serotonin system and support previous studies suggesting that reduced 5-HT1AR density during development might be a factor increasing vulnerability to stress-related neuropsychiatric disorders. Furthermore, alterations in the serotonin system seemed to be gender- and region-specific, providing a biological basis for the higher prevalence of affective disorders in women.
Journal: Biological Psychiatry - Volume 67, Issue 12, 15 June 2010, Pages 1146–1153