کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4178936 | 1276522 | 2011 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Methamphetamine Self-Administration Produces Attentional Set-Shifting Deficits and Alters Prefrontal Cortical Neurophysiology in Rats Methamphetamine Self-Administration Produces Attentional Set-Shifting Deficits and Alters Prefrontal Cortical Neurophysiology in Rats](/preview/png/4178936.png)
BackgroundChronic methamphetamine abusers exhibit deficits in tasks requiring intact prefrontal cortex function, and prefrontal cortex dysfunction has been implicated in the loss of control over drug use. This study used a combination of behavioral and electrophysiologic assessments in rats with a history of long access methamphetamine self-administration to determine methamphetamine-induced changes in prefrontal cortex–dependent attentional set-shifting performance, drug-seeking, and prefrontal cortex neuronal activity.MethodsMale Long–Evans rats self-administered methamphetamine (.02 mg/infusion, intravenous) or received yoked saline infusions for 6 hours a day for 14 days. Cognitive flexibility was assessed using an attentional set-shifting task before 2 weeks of self-administration and 1 day after self-administration. Animals then underwent 11 days of abstinence, followed by three subsequent tests for context-induced drug seeking. Finally, animals were anesthetized, and single-unit in vivo extracellular recordings were performed in the dorsomedial prefrontal cortex.ResultsMethamphetamine-experienced rats showed escalated drug intake and context-induced drug-seeking following abstinence. During the extradimensional set-shift component, meth-experienced rats showed selective impairments that were identical to deficits produced by excitotoxic lesions of the prefrontal cortex. Rats with a history of chronic methamphetamine intake also exhibited higher basal firing frequency and a significantly greater proportion of burst-firing cells in the prefrontal cortex compared with yoked-saline controls.ConclusionsPrefrontal cortex–specific alterations in neuronal function may play a key role in methamphetamine-induced attentional deficits and drug-seeking. These data support the possibility that targeting prefrontal cortex pathology may improve treatment outcome in methamphetamine addiction.
Journal: Biological Psychiatry - Volume 69, Issue 3, 1 February 2011, Pages 253–259