Catechol-O-Methyltransferase Valine158Methionine Genotype and Resting Regional Cerebral Blood Flow in Medication-Free Patients with Schizophrenia

In schizophrenia, brain structures important for executive and affective processing show activity that is differentially predicted by COMT allelic variation in an opposing manner even at rest, providing evidence for the salience of prefrontal dopaminergic tone in task-independent, basal-level neural activity.