کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4179354 1276545 2009 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Gene × Environment Interactions at the Serotonin Transporter Locus
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Gene × Environment Interactions at the Serotonin Transporter Locus
چکیده انگلیسی

BackgroundAlthough it is universally accepted that human disease and behavior depend upon both environmental and genetic variation, a view supported by family and twin studies, examples of environmental interactions with genes identified at the molecular level (G × E) are not so well established.MethodsWe carried out a systematic review and meta-analysis of the serotonin transporter (5-HTTLPR) polymorphic region × stressful life event (SLE) literature and investigated to what extent the main effects reported in this literature are consistent with a number of G × E hypotheses. Our aim was to provide a framework in which to assess the robustness of the claim for the presence of an interaction.ResultsThe results from our systematic review and meta-analysis indicate that the main effect of 5-HTTLPR genotype and the interaction effect between 5-HTTLPR and SLE on risk of depression are negligible. We found that only a minority of studies report a replication that is qualitatively comparable to that in the original report.ConclusionsGiven reasonable assumptions regarding likely genetic and environmental effect sizes, our simulations indicate that published studies are underpowered. This, together with other aspects of the literature, leads us to suggest that the positive results for the 5-HTTLPR × SLE interactions in logistic regression models are compatible with chance findings.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biological Psychiatry - Volume 65, Issue 3, 1 February 2009, Pages 211–219
نویسندگان
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