کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4179500 1276552 2008 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Inactivation of the 5-HT7 Receptor Partially Blocks Phencyclidine-Induced Disruption of Prepulse Inhibition
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Inactivation of the 5-HT7 Receptor Partially Blocks Phencyclidine-Induced Disruption of Prepulse Inhibition
چکیده انگلیسی

BackgroundStudies have implicated the serotonin (5-HT)7 receptor in physiological and pathophysiological phenomena, including thermoregulation, central control of micturition and locomotion, regulation of circadian rhythm, sleep, and depression. Further, several antidepressant and antipsychotic drugs have high affinity for the 5-HT7 receptor.MethodsWe examined the role of 5-HT7 receptors in a rodent analogue of sensorimotor gating deficits in schizophrenia: phencyclidine (PCP)-induced disruption of prepulse inhibition (PPI) of acoustic startle. We used mice lacking the 5-HT7 receptor due to a targeted inactivation of this receptor gene and the selective 5-HT7 receptor antagonist SB-269970.ResultsSB-269970 did not affect either baseline PPI or PCP-disrupted PPI. There was no difference between 5-HT7+/+ and 5-HT7−/− mice in startle reactivity or PPI regardless of prepulse intensity (74–82 dB), interstimulus interval (25–500 msec), or pulse intensity (90–120 dB). Nevertheless, disruption of PPI produced by PCP (10 mg/kg) in wild-type mice was reduced in 5-HT7−/− mice, although it was not affected by the 5-HT7 antagonist SB-269970. By contrast, the PPI-disruptive effects of apomorphine (5 mg/kg) and amphetamine (7.5 mg/kg) were comparable in both genotypes.ConclusionsThe results indicate a partial role for the 5-HT7 receptor in the glutamatergic PPI model of sensorimotor gating deficits in schizophrenia that is sensitive to atypical antipsychotics and no involvement of this receptor in the dopaminergic PPI model that is sensitive to typical antipsychotics. Thus, the 5-HT7−/− mice may provide a useful tool to study the role of 5-HT7 receptor in the action of atypical antipsychotic drugs and schizophrenia.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biological Psychiatry - Volume 63, Issue 1, 1 January 2008, Pages 98–105
نویسندگان
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