کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4180294 1276597 2007 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Chronic Unpredictable Stress Decreases Cell Proliferation in the Cerebral Cortex of the Adult Rat
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Chronic Unpredictable Stress Decreases Cell Proliferation in the Cerebral Cortex of the Adult Rat
چکیده انگلیسی

BackgroundOne of the most consistent morphologic findings in postmortem studies of brain tissue from depressed patients is a decrease in the number of glia in the prefrontal cortex. However, little is known about the mechanisms that contribute to this decrease in cell number.MethodsTo address this question, we subjected adult rats to chronic stress, a vulnerability factor for depression, and measured cell proliferation as a potential cellular mechanism that could underlie glial reduction in depression.ResultsWe found that exposure to chronic unpredictable stress (CUS) for 15 days significantly decreased cell proliferation in neocortex by approximately 35%. This effect was dependent on the duration, intensity and type of stress, and was region-specific. Analysis of cell phenotype demonstrated that there was a decrease in the number of oligodendrocytes and endothelial cells. Finally, using a CUS paradigm that allows for analysis of anhedonia, we found that chronic antidepressant administration reversed the decrease in cortical cell proliferation, as well as the deficit in sucrose preference.ConclusionThese findings are consistent with the possibility that decreased cell proliferation could contribute to reductions in glia in prefrontal cortex of depressed subjects and further elucidate the cellular actions of stress and antidepressants.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biological Psychiatry - Volume 62, Issue 5, 1 September 2007, Pages 496–504
نویسندگان
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