کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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4180681 | 1276615 | 2007 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Relationship Between Neuroticism Personality Trait and Serotonin Transporter Binding Relationship Between Neuroticism Personality Trait and Serotonin Transporter Binding](/preview/png/4180681.png)
BackgroundPersonality trait is thought to be one of the important factors for vulnerability to depression. The relation between serotonin transporter (5-HTT) polymorphism and anxiety-related personality has been investigated in genetic research. In this study, we investigated the relation between in vivo regional 5-HTT binding in the brain and personality inventory measures in normal male volunteers.MethodsThirty-one healthy male volunteers underwent positron emission tomography scans with 11C-labeled 3-amino-4-(2-dimethylaminomethyl-phenylsulfanyl) benzonitrile ([11C]DASB) to measure 5-HTT and completed revised NEO Personality Inventory. Correlation of [11C]DASB binding potentials (BP) with personality inventory measures was calculated using region-of-interest analysis and statistical parametric mapping based on the BP images.ResultsNeuroticism was positively correlated with 5-HTT binding in the thalamus (p = .004). No significant correlation was observed in any other brain region. Within the neuroticism dimension, the facet of depression was positively correlated with 5-HTT binding in the thalamus (p = .001).ConclusionsSubjects with higher thalamic 5-HTT binding are more likely to express higher levels of neuroticism and depressive feeling. Serotonin transporter binding in the thalamus might be a marker of vulnerability to depression.
Journal: Biological Psychiatry - Volume 62, Issue 6, 15 September 2007, Pages 588–592