کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4180805 1276620 2008 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A Common Genetic Predisposition to Stress Sensitivity and Stress-Induced Nicotine Craving
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
A Common Genetic Predisposition to Stress Sensitivity and Stress-Induced Nicotine Craving
چکیده انگلیسی

BackgroundClinical studies have shown that stress is one of the main causes for relapse in abstinent smokers. In this article, we have asked whether animals with a genetic predisposition to high or low stress responsivity differ in behaviors relevant to nicotine addiction, in particular stress-induced reinstatement of drug addiction.MethodsFirst, we selected animals with high, low, and average stress sensitivity from the F2 generation from an intercross of high (C57BL/6J) and low (C3H/J) emotional mouse strains. Next, these animals were trained to self-administer nicotine through a chronic intravenous catheter. After extinction of the operant behavior replacing nicotine with saline, mice were stressed with a foot shock and the reinstatement of drug-seeking behaviors was evaluated.ResultsMice with different stress reactivity showed no difference in the acquisition, extinction, or level of nicotine self-administration. We found an immediate reinstatement of drug-seeking behavior in high stress reactive mice, in contrast to low or average stress reactive animals, which showed no significantly increased activity at the active (nicotine-associated) sensor.ConclusionsWe conclude that a genetic predisposition to high stress sensitivity contributes to relapse vulnerability but not to the initiation or maintenance of nicotine consumption.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biological Psychiatry - Volume 63, Issue 2, 15 January 2008, Pages 164–171
نویسندگان
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