کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4180942 1276625 2007 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Oxytocin Attenuates Amygdala Responses to Emotional Faces Regardless of Valence
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Oxytocin Attenuates Amygdala Responses to Emotional Faces Regardless of Valence
چکیده انگلیسی

BackgroundOxytocin is known to reduce anxiety and stress in social interactions as well as to modulate approach behavior. Recent studies suggest that the amygdala might be the primary neuronal basis for these effects.MethodsIn a functional magnetic resonance imaging study using a double-blind, placebo-controlled within-subject design, we measured neural responses to fearful, angry, and happy facial expressions after intranasal application of 24 IU oxytocin compared with placebo.ResultsOxytocin reduced right-sided amygdala responses to all three face categories even when the emotional content of the presented face was not evaluated explicitly. Exploratory whole brain analysis revealed modulatory effects in prefrontal and temporal areas as well as in the brainstem.ConclusionsResults suggest a modulatory role of oxytocin on amygdala responses to facial expressions irrespective of their valence. Reduction of amygdala activity to positive and negative stimuli might reflect reduced uncertainty about the predictive value of a social stimulus and thereby facilitates social approach behavior.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biological Psychiatry - Volume 62, Issue 10, 15 November 2007, Pages 1187–1190
نویسندگان
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