Diplotypes of the Human Serotonin 1B Receptor Promoter Predict Growth Hormone Responses to Sumatriptan in Abstinent Alcohol-Dependent Men

A blunting of GH responses in abstinent AD men was observed only among those with the most common HTR1B promoter diplotype. Less common promoter diplotypes appeared protective. Controlling for genetic background is a useful augmentation of case-control pharmacological challenge strategies designed to elucidate the psychobiology of AD and other complex disorders.