کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4181036 1276631 2007 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Medial Frontal Hyperactivity in Reality Distortion
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Medial Frontal Hyperactivity in Reality Distortion
چکیده انگلیسی

BackgroundSchizophrenia/schizoaffective disorder involves reality distortion (RD), which impairs the ability to process socioemotional information. Because this psychological capacity maps to the medial prefrontal cortex (MPFC) and schizophrenia involves abnormal MPFC function, we tested the hypothesis that treated schizophrenic/schizoaffective patients with persistent RD (RD+) would exhibit greater MPFC dysfunction than patients without significant RD (RD−). The amygdala interacts with MPFC, also carries out socioemotional processing, and has been implicated in schizophrenia; thus, we also tested the hypothesis that patients would exhibit aberrant amygdala activity.MethodsEleven RD+ patients, 12 RD− patients, and 15 healthy control subjects (HC) viewed emotionally salient pictures with neutral, aversive, and positive content during the acquisition of blood oxygenation level-dependent (BOLD) sensitive functional magnetic resonance imaging.ResultsAll groups had similar behavioral responses to the pictures. The RD+ subjects had greater BOLD responses (compared with the RD− and HC groups) to the aversive pictures in the anterior MPFC. Both patient groups showed reduced activation in MPFC and the left amygdala (compared with HC) for neutral pictures (compared with blank condition), although this effect could be explained by medication.ConclusionsReality distortion is associated with hyperactivity of the MPFC in schizophrenic/schizoaffective patients whose symptoms persist in spite of antipsychotic treatment.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biological Psychiatry - Volume 61, Issue 10, 15 May 2007, Pages 1171–1178
نویسندگان
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