کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4181040 1276631 2007 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A Genetic Variant of the Serine Racemase Gene Is Associated with Schizophrenia
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
A Genetic Variant of the Serine Racemase Gene Is Associated with Schizophrenia
چکیده انگلیسی

BackgroundSerine racemase (SRR) is a brain-enriched enzyme that converts l-serine to d-serine, which acts as an endogenous ligand of N-methyl d-aspartate (NMDA) receptors. Dysfunction of SRR may reduce the function of NMDA receptors and susceptibility to schizophrenia.MethodsWe genotyped three single-nucleotide polymorphisms (SNPs) of the 5′ region of the SRR gene in 525 patients with schizophrenia and 524 healthy controls. Effects of SNPs on the promoter activity and on serum levels of total and d-serine were examined.ResultsWe found a significant excess of the IVS1a+465C allele of the SRR gene in schizophrenia, especially in the paranoid subtype (p = .0028). A reporter assay showed that the IVS1a+465C allele had 60% lower promoter activity than did the IVS1a+465G allele.ConclusionsThe IVS1a+465C allele of the SRR gene, which reduces expression of the gene, is a risk factor for schizophrenia, especially the paranoid subtype.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biological Psychiatry - Volume 61, Issue 10, 15 May 2007, Pages 1200–1203
نویسندگان
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