کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4181234 1276644 2006 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mineralocorticoid Receptor Function in Posttraumatic Stress Disorder After Pretreatment with Metyrapone
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Mineralocorticoid Receptor Function in Posttraumatic Stress Disorder After Pretreatment with Metyrapone
چکیده انگلیسی

BackgroundAlterations of mineralocorticoid receptor (MR) mediated negative feedback inhibition of cortisol might contribute to abnormalities of hypothalamic-pituitary adrenal (HPA) activity in posttraumatic stress disorder (PTSD).MethodsIn a placebo-controlled study, we examined 11 subjects with PTSD and 11 healthy controls between 14:00 and 21:00. After pretreatment with 3 g metyrapone to inhibit basal endogenous cortisol secretion, subjects orally received in randomized order .5 mg of the MR agonist fludrocortisone or placebo. Adrenocorticotropic hormone (ACTH), cortisol, and 11-deoxycortisol were measured every 30 min until 21:00.ResultsCompared to placebo, fludrocortisone led to a significant decrease of ACTH and cortisol that was similar in both groups. Subjects with PTSD had higher raw cortisol and higher normed (baseline-related) ACTH and 11-deoxycortisol values after metyrapone independent of treatment with fludrocortisone or placebo.ConclusionsWhile HPA responses after metyrapone seem to be stronger in PTSD compared to controls, no alterations of mineralocorticoid receptor function in PTSD were found in this study.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biological Psychiatry - Volume 60, Issue 7, 1 October 2006, Pages 784–787
نویسندگان
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