کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4181370 | 1276659 | 2006 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Placental Passage of Tricyclic Antidepressants Placental Passage of Tricyclic Antidepressants](/preview/png/4181370.png)
BackgroundThe use of antidepressants during pregnancy continues to garner considerable attention, though there are limited investigations that have sought to quantify fetal exposure.MethodsMaternal and umbilical cord sera were collected at delivery from ten women taking nortriptyline and seven taking clomipramine. Placental passage was calculated as the ratio of umbilical cord to maternal serum concentration. Obstetrical outcome data were gathered from subjects at delivery.ResultsThe placental passage ratio of nortriptyline and its active metabolite, cis-10-hydroxynortriptyline, were .68 ± .40, 1.40 ± 2.40, respectively. Clomipramine and desmethylclomipramine ratios were .60 ± .50, .80 ± .60. Obstetrical complications, such as pre-term delivery and pregnancy induced hypertension, were increased compared to the national average.ConclusionsThe in vivo ratios of umbilical cord to maternal serum drug concentrations demonstrate considerable fetal exposure and differ greatly from previous results utilizing ex vivo perfusion.
Journal: Biological Psychiatry - Volume 59, Issue 3, 1 February 2006, Pages 287–290