Étifoxine, neurostéroïdes et anxiété

All of our data indicate that etifoxine facilitates GABAergic inhibition by two types of action: [1] by directly potentiating the activity of GABAA receptors via an allosteric modulatory different site from that of the benzodiazepines, and [2] by stimulating the production of 3α5α-NS, which in turn potentiate the activity of GABAA receptors. These two effects are independent and additive. They therefore contribute to make GABAergic transmission more effective.