کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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4185789 | 1277377 | 2007 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Language lateralization in monozygotic twins discordant and concordant for schizophrenia. A functional MRI pilot study Language lateralization in monozygotic twins discordant and concordant for schizophrenia. A functional MRI pilot study](/preview/png/4185789.png)
AimPrevious studies have suggested altered structural and functional asymmetry of the brain in schizophrenia.MethodsFunctional MRI was used to assess differences in cortical activation during a verbal task in Broca's area and its contralateral homologue in four pairs of right-handed monozygotic (MZ) twins discordant and concordant for schizophrenia with low and high familial loading for the illness and four healthy control MZ twin pairs.ResultsPooled data from all subjects with schizophrenia showed increased activation in the right homologue of Broca's area in contrast to healthy individuals. Concordant twins (i.e. high familial loading group) showed prominent between co-twin differences in lateralization index within given region of interest. Intra-pair differences in lateralization index were significantly higher in concordant twins compared to the controls (0.69 ± 0.4 vs. 0.13 ± 0.13, P < 0.03), albeit no significant differences in the variable were shown between the discordant and control groups.ConclusionThis study provides evidence of reduced cerebral dominance for language processing in patients with schizophrenia. The findings further suggest the need for additional research on relative proportion of genetic and environmental factors underlying deviations of functional asymmetry in schizophrenia.
Journal: European Psychiatry - Volume 22, Issue 5, July 2007, Pages 319–322