کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4188804 | 1278028 | 2011 | 15 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
¿Suspender o no el tratamiento? ¿Durante cuánto tiempo debe mantenerse el tratamiento farmacológico del trastorno por déficit de atención/hiperactividad?
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کلمات کلیدی
AtomoxetinaClinical trials - آزمایشات بالینیEnsayos clínicos - آزمایشات بالینیatomoxetine - اتموکسیدینSide-effects - اثرات جانبیAttention-deficit hyperactivity disorder (ADHD) - اختلال بیش فعالی کمبود توجه (ADHD)Safety - ایمنیSeguridad - ایمنیLong-term treatment - درمان درازمدتPsychostimulants - روانشناسیEfectos secundarios - عوارض جانبی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
روانپزشکی و بهداشت روانی
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چکیده انگلیسی
Attention-deficit hyperactivity disorder (ADHD) is a common neuropsychiatric disorder with a strong persistence over time. Medication is frequently used in the clinical management of ADHD. After response, medication is typically prescribed for months to years. It is unclear whether extended medication treatment provides long-term benefits and how long it should be continued. Furthermore, there is concern about the long-term safety of ADHD medication. The aim of this systematic review is to address these issues and provide recommendations about the decision to stop or not to stop ADHD medication. We performed a search in PubMed and focused on medication studies with a treatment longer than 12Â weeks in subjects 6-18Â years old. Extended placebo-controlled double-blind parallel studies are not available. Placebo-controlled discontinuation studies and prospective long-term observational treatment studies provide evidence that medication management leads to a substantial reduction of ADHD symptoms and less impairment of functioning for a period of about 2 years. There is limited and inconsistent evidence for long-term advantage of medication treatment beyond symptom control, such as improved social functioning, academic achievement, employment status and less adverse psychiatric outcome. In terms of safety, long-term effects of medication on growth, blood pressure and heart rate are limited and the occurrence of suicidal, psychotic and manic symptoms is rare. Animal data about neurotoxic effects of psycho stimulants cannot be directly extrapolated to humans. Therefore, clinical decisions about starting, continuing, and stopping of ADHD medication should be made on an individual basis. Medication free periods should be implemented at regular times to investigate the need for an ongoing benefit of medication. Unfounded assumptions about continuing benefit of medication use should be abandoned. Careful monitoring of side effects is necessary and must be able to detect early alarming signals.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: PsiquiatrÃa Biológica - Volume 18, Issue 4, OctoberâDecember 2011, Pages 153-167
Journal: PsiquiatrÃa Biológica - Volume 18, Issue 4, OctoberâDecember 2011, Pages 153-167
نویسندگان
Gigi H.H. van de Loo-Neus, Nanda Rommelse, Jan K. Buitelaar,