Relaciones entre epilepsia y psicosis: de la clínica a la neurobiología

The results show that clinical evaluation and neuropsychology provide no basis for differentiation. In contrast, neuroimaging highlights several distinguishing features, i.e. the amygdala is larger in patients with POE than in those with schizophrenia. Neurophysiology shows significant differences in the N-100 component of auditory evoked potentials between POE and schizophrenia. The physiopathological hypotheses that address POE are more complex than those addressing schizophrenia since, in addition to the neurodevelopment disorder and the physical-chemical and environmental postnatal traumas, they add a new component, namely the presence of neurochemical disorders caused by repeated electrical disorders (kindling effect). Despite the progress made in research techniques in the neurosciences, more investigation is required to clarify the etiology and physiopathology of POE and schizophrenia. In addition, the development of further objective clinical tools would improve differential diagnoses.