کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4339815 | 1295768 | 2009 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The absence of a functional peroxisome proliferator-activated receptor-alpha gene in mice enhances motor sensitizing effects of morphine, but not cocaine
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کلمات کلیدی
RXRVTAIL-2NF-κBIL-1βPMSFRetinoid X receptorIL-12PPARPPAR-αCOX-2WY14643N-methyl-d-aspartate receptor 1phenylmethanesulphonylfluorideDMSO - DMSOperoxisome proliferator-activated receptor alpha - آلفای گیرنده پرولیفراتور فعال فعالEDTA - اتیلن دی آمین تترا استیک اسید Ethylenediaminetetraacetic acid - اتیلینیدامین تتراستیک اسیدNeuroinflammation - التهاب عصبیinterleukin-12 - اینترلوکین -12Interleukin-1β - اینترلوکین-1βInterleukin-2 - اینترلوکین-۲tyrosine hydroxylase - تیروزین هیدروکسیلازSensitization - حساسیتDimethyl sulfoxide - دیمتیل سولفواکسیدcyclooxigenase-2 - سیکلوکسی ژناز-2morphine - مورفینHPA - میلی بار یا هکتوپاسکالventral tegmental area - ناحیه تگمنتوم شکمیknock out - ناک اوتwild-type - نوع وحشیhypothalamic-pituitary-adrenal - هیپوتالاموس-هیپوفیز-آدرنالCocaine - کوکائین
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
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چکیده انگلیسی
Neuroinflammation of the CNS seems to participate in sensitizing effects of drugs of abuse such as psychostimulants and morphine. The nuclear receptor peroxisome proliferator-activated receptor alpha (PPAR-α) plays a prominent role in several physiological processes including the inflammatory response, and its activation mediates a reduced production of pro-inflammatory factors. The objectives were to examine the involvement of nuclear PPAR-α in motor sensitization to morphine and cocaine, by using null mice (PPAR-α â/âmice), or the injection of a selective PPAR-α agonist, [[4-chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl] thio]acetic acid (WY14643), in morphine-treated mice. The findings indicate that PPAR-α plays an inhibitory role in the expression (not induction) of motor sensitization to morphine, but it is devoid of effects on sensitization to cocaine, suggesting that this nuclear receptor participates in motor activating effects of opiates but not psychostimulants. Furthermore, brain PPAR-α expression is upregulated after the highest dose of repeated morphine, but not chronic cocaine, suggesting that this receptor could play a homeostatic role. In accordance, systemic WY14643 was able to block sensitization to morphine, confirming that PPAR-α plays a homeostatic role opposing morphine-induced motor sensitization, likely through a reduction of inflammation-associated changes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 164, Issue 2, 1 December 2009, Pages 667-675
Journal: Neuroscience - Volume 164, Issue 2, 1 December 2009, Pages 667-675
نویسندگان
E. Fernandez-Espejo, S. Ramiro-Fuentes, F. Rodriguez de Fonseca,