کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4477148 | 1315711 | 2008 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Ras gene in marine mussels: A molecular level response to petrochemical exposure Ras gene in marine mussels: A molecular level response to petrochemical exposure](/preview/png/4477148.png)
Mussels are susceptible to numerous toxicants and are often employed as bioindicators. This study investigated the status of the ras proto-oncogene in Mytilus galloprovincialis following petrochemical exposure. A M. galloprovincialis homologue of the vertebrate ras gene was isolated, showing conserved sequence in regions of functional importance and a high incidence of polymorphic variation. Mutational damage was investigated in mussels chronically exposed to the water-accommodated fraction of #4 fuel-oil (WAF), and in mussels collected along the NW coast of Portugal in sites with different levels of petrochemical contamination. A ras gene point mutation was identified in the codon 35 of one individual exposed to 12.5% WAF. No mutations were detected in mussels from the WAF control or environmental samples. This represents the first report of a ras gene mutation, experimentally-induced by petrochemical exposure, in an invertebrate species.
Journal: Marine Pollution Bulletin - Volume 56, Issue 4, April 2008, Pages 633–640