کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4638625 1632016 2015 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Diffusion, viscoelasticity and erosion: Analytical study and medical applications
ترجمه فارسی عنوان
نفوذ، ویسکوزلوزیتی و فرسایش: مطالعه تحلیلی و برنامه های پزشکی
موضوعات مرتبط
مهندسی و علوم پایه ریاضیات ریاضیات کاربردی
چکیده انگلیسی
Erodible viscoelastic materials, as biodegradable polymers, have a huge range of applications in medicine to make drug eluting implants. Using the mathematical model the behavior of a particular ocular drug eluting implant which describes drug delivery into the vitreous chamber of the eye is presented. The model consists of coupled systems of partial differential equations linked by interface conditions. The chemical structure, the viscoelastic properties and the diffusion in the implant as well as the transport in the vitreous are taken into account to simulate the evolution in vivo of released drug. The dependence of the delivery profile on the properties of the material is addressed. Numerical simulations that illustrate the interplay between these phenomena are included.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Computational and Applied Mathematics - Volume 275, February 2015, Pages 489-501
نویسندگان
, , , ,