کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4935113 | 1434066 | 2016 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Morphometric analysis of the cerebral expression of ATP-binding cassette transporter protein ABCB1 in chronic schizophrenia: Circumscribed deficits in the habenula
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کلمات کلیدی
MDR1MTGkDakiloDaltonITGABCB1ANCOVAinfDSM-IVHabenula - habenulaSchizophrenia - اسکیزوفرنی یا شیزوفرنیImmunohistochemistry - ایمونوهیستوشیمیinterferon - اینترفرونinterleukin - اینترلوکینanalysis of covariance - تجزیه و تحلیل کوواریانسLeft - ترک کردright - درستCNS - دستگاه عصبی مرکزیBlood–brain barrier - سد خونی مغزیcentral nervous system - سیستم عصبی مرکزیdentate gyrus - شکنج دندانه دارInferior temporal gyrus - قارچ قاعدگی پایینmultidrug resistance protein 1 - پروتئین مقاومتی چند دارویی 1cingulate gyrus - گودرزی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
There is increasing evidence that microvascular abnormalities and malfunction of the blood-brain barrier (BBB) significantly contribute to schizophrenia pathophysiology. The ATP-binding cassette transporter ABCB1 is an important molecular component of the intact BBB, which has been implicated in a number of neurodegenerative and psychiatric disorders, including schizophrenia. However, the regional and cellular expression of ABCB1 in schizophrenia is yet unexplored. Therefore, we studied ABCB1 protein expression immunohistochemically in twelve human post-mortem brain regions known to play a role in schizophrenia, in 13 patients with schizophrenia and nine controls. In ten out of twelve brain regions under study, no significant differences were found with regard to the numerical density of ABCB1-expressing capillaries between all patients with schizophrenia and control cases. The left and right habenular complex, however, showed significantly reduced capillary densities in schizophrenia patients. In addition, we found a significantly reduced density of ABCB1-expressing neurons in the left habenula. Reduced ABCB1 expression in habenular capillaries might contribute to increased brain levels of proinflammatory cytokines in patients with schizophrenia, while decreased expression of this protein in a subpopulation of medial habenular neurons (which are probably purinergic) might be related to abnormalities of purines and their receptors found in this disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Schizophrenia Research - Volume 177, Issues 1â3, November 2016, Pages 52-58
Journal: Schizophrenia Research - Volume 177, Issues 1â3, November 2016, Pages 52-58
نویسندگان
Hans-Gert Bernstein, Jens Hildebrandt, Henrik Dobrowolny, Johann Steiner, Bernhard Bogerts, Jens Pahnke,