Natural lipids enriched self-nano-emulsifying systems for effective co-delivery of tamoxifen and naringenin: Systematic approach for improved breast cancer therapeutics

The oral administration of TMX-NG-SNEDDS leads to nano micelles formation in situ to owing to presence of the smart ingredients, which leads its lymphatic uptake, and multiple fold enhanced bioavailability revealed through pharmacokinetics parameters; the results corroborated the same using cell cytotoxicity on MCF-7 cells and flow cytometry of the samples with more than 84% apoptosis. The natural ingredients however, marked safe and effective role of the optimized formulation as evident from caco-2 cell line studies and Kaplan survival curve, % tumor burden after treatment period.214