کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5040639 | 1473903 | 2017 | 7 صفحه PDF | دانلود رایگان |
- Increases in CRP from childhood to adolescence predict sleep apnea in adolescence.
- Increased waist circumference correlates with CRP increases in boys.
- During adolescence, boys develop more central adiposity than girls.
- Inflammation mediates the association between waist circumference and apnea severity.
While chronic systemic inflammation in obstructive sleep apnea (OSA) has been traditionally considered a consequence of intermittent hypoxia, several treatment studies targeting inflammation suggest that this process may precede the development of the disorder. A recent cross-sectional study in the Penn State Child Cohort (PSCC) revealed that inflammation largely mediates the association between visceral adiposity and OSA in adolescence. The purpose of this study was to examine for the first time whether, longitudinally, inflammation precedes OSA during this developmental period. A subsample of the PSCC with longitudinal sleep and inflammation data (n = 51) was included in this study. Participants underwent 9-h polysomnography (22:00-7:00), physical exam, and fasting morning blood draw at both time points. Plasma C-reactive protein (CRP) was measured via ELISA. At follow-up, visceral, subcutaneous, and total fat area were assessed via dual X-ray absorptiometry. Sex differences in body composition emerged in adolescence, with boys having more visceral adiposity than girls. Longitudinal increases in waist circumference from childhood to adolescence were associated with increases in CRP (ÎCRP) and follow-up CRP in boys, but not girls. Furthermore, in boys, ÎCRP was associated with higher follow-up apnea/hypopnea index (AHI). When ÎCRP was entered into a model predicting follow-up AHI, Îwaist circumference was no longer significant, indicating that inflammation largely explains the association between increasing central obesity and OSA severity. These preliminary findings, in a longitudinal, non-clinical sample of children developing OSA, suggest that inflammation derived from visceral adipose tissue precedes the development of the disorder, suggesting a potential causal mechanism.
Journal: Brain, Behavior, and Immunity - Volume 64, August 2017, Pages 259-265