کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5141621 1495877 2017 24 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Analytical methodology for determination of interactions between metallodrugs and DNA: A critical examination
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Analytical methodology for determination of interactions between metallodrugs and DNA: A critical examination
چکیده انگلیسی
Cellular DNA is generally accepted as major pharmacological target of the majority of metal-based drugs. Although there are certain gaps in this paradigm, it is not an overstatement to say that almost every second report on testing novel metal complexes or organometallic compounds with potential pharmacological activity implicates studying their binding to DNA. Metallodrug-DNA interactions can be detected and assessed through determining adduct formation, binding-induced conformational changes of DNA, and DNA degradation using a variety of analytical techniques. Here we critically review the existing arsenal of strategies and approaches, with the objective to reveal and give rise to development of those techniques that can provide information on the speciation changes of a designated metal upon binding to DNA in ex-vivo samples. Also reflecting our current research interests, emphasis is given to anticancer metallodrugs and drug candidates. Owing to the complexity of the topic, we focus on binding studies in which only the entire DNA molecule (not its various structure fragments) is used.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: TrAC Trends in Analytical Chemistry - Volume 90, May 2017, Pages 107-113
نویسندگان
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