کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5156850 1500584 2017 28 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Preparation and characterization of a composite biomaterial including starch micro/nano particles loaded chitosan gel
ترجمه فارسی عنوان
آماده سازی و مشخص نمودن مواد بیولوژیکی کامپوزیت از جمله نشاسته های میکرو / نانو ذرات، ژل کیتوزان لود شده
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی
Thermosensitive Chitosan hydrogels which can be injected into defects with minimally invasive approach were prepared. Also starch micro/nano particles were synthesized via water-in-oil (W/O) miniemulsion technique. The starch particles were incorporated into the chitosan hydrogel to prepare injectable thermosensitive hydrogel composites. Tube inverting method, compression tests, swelling studies, XRD, SEM, OM, DLS, UV-vis spectroscopy were used for investigations. Results revealed that increasing crosslinker and surfactant contents and stirring rate leads to particle size reduction. Particle size was modeled using design of experiments (DOE) via the response surface method (RSM). Due to analysis of variance (ANOVA), the particle sizes can be predicted by quadratic model within the design space. Gelation time and compressive modulus measurements showed the particles significant influence on the blend network density and hydrogel mechanical properties. Swelling measurements revealed that incorporation of starch particles in chitosan hydrogel increases its swelling coefficient significantly. The innovative architecture, namely micro/nano particles in gel can be considered as a dual delivery platform or smart scaffold for engineering of certain tissues.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 174, 15 October 2017, Pages 633-645
نویسندگان
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