کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5157690 | 1500591 | 2017 | 39 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Fabrication and evaluation of thermosensitive chitosan/collagen/α, β-glycerophosphate hydrogels for tissue regeneration
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کلمات کلیدی
Calcein-AM (PubChem CID: 4126474)MTT (PubChem CID: 64965)Acetic acid (PubChem CID: 176) - اسید استیک (PubChem CID: 176)Characterization - تعیین مشخصاتBiocompatibility - زیست سازگاری3D cell culture - فرهنگ سلولی 3DThermosensitive hydrogel - هیدروژل حساس به حرارتPotassium bromide (PubChem CID: 253877) - پتاسیم برومید (PubChem CID: 253877)Acid-soluble collagen - کلاژن محلول اسیدSodium chloride (PubChem CID: 5234) - کلرید سدیم (PubChem CID: 5234)Chitosan (PubChem CID: 71853) - کیتوزان (PubChem CID: 71853)Chitosan - کیتوسان
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Thermosensitive hydrogels whose physiological properties are similar to extracellular matrix have been extensively used for tissue regeneration. Polysaccharides and proteins, as biocompatible substrates similar to bio-macromolecules that could be recognized by human body, are two preferred polymers for fabrication of such hydrogels. A series of novel thermosensitive hydrogels (CS-ASC-HGs) containing chitosan (CS) and acid-soluble collagen (ASC) were thus prepared, in the presence of α, β-glycerophosphate, to mimic extracellular microenvironment for tissue regeneration. Rheological measurements demonstrated excellent thermosensitivity. FT-IR and SEM indicated CS-ASC-HGs possessed 3D porous architectures with fibrous ASC, and the molecular structure of ASC was well-maintained in hydrogels. Hemolysis, acute toxicity, and cytotoxicity tests suggested CS-ASC-HGs were of good biocompatibility. CS-ASC-HGs were able to support the survival and proliferation of L929 cells encapsulated in them. Moreover, CS-ASC-HGs had better pH stability and biocompatibility than pure CS hydrogel. These results suggested that CS-ASC-HGs could serve as promising scaffolds for tissue regeneration.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 167, 1 July 2017, Pages 145-157
Journal: Carbohydrate Polymers - Volume 167, 1 July 2017, Pages 145-157
نویسندگان
Qifeng Dang, Kai Liu, Zhenzhen Zhang, Chengsheng Liu, Xi Liu, Ying Xin, Xiaoyu Cheng, Tao Xu, Dongsu Cha, Bing Fan,