کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5408075 1506531 2017 32 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Experimental solubility data for prednisolone and hydrocortisone in various solvents between (293.2 and 328.2) K by employing combined DTA/TGA
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی تئوریک و عملی
پیش نمایش صفحه اول مقاله
Experimental solubility data for prednisolone and hydrocortisone in various solvents between (293.2 and 328.2) K by employing combined DTA/TGA
چکیده انگلیسی
Solubility measurements were performed for the systems (11β)-11,17,21-trihydroxypregna-1,4-diene-3,20-dione (prednisolone) and (11β)-11,17,21-trihydroxypregn-4-ene-3,20-dione (hydrocortisone) in 10 solvents at atmospheric pressure within the temperature range, T = (293.2 to 328.2) K by employing combined digital thermal analysis and thermal gravimetric analysis (DTA/TGA) to determine liquid phase compositions at saturation. The maximum solubility for prednisolone and hydrocortisone was in N,N dimethylformamide at 328.2 K with x1 = 0.0141 and x1 = 0.0142 respectively. The lowest solubility was found to be prednisolone and hydrocortisone in water at 293.2 K with x1 = 0.0000105 and x1 = 0.0000115 respectively. The composition data was modelled using the Tsuboka-Katayma modified Wilson and NRTL activity coefficient models. There is satisfactory agreement between the experimental results and the models chosen. Furthermore, melting points and enthalpies of fusion of prednisolone and hydrocortisone were determined by combined DTA/TGA. The enthalpy of fusion and melting point of prednisolone and hydrocortisone was found to be 36,145 J·mol− 1 and 514.5 K and 33,900 J·mol− 1 and 486.1 K respectively.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Liquids - Volume 240, August 2017, Pages 303-312
نویسندگان
, , ,