Investigation of the inclusion behavior of ofloxacin with methyl-β-cyclodextrin

Me-β-CD was most suitable for inclusion of the neutral ofloxacin form and the major inclusion interactions between the guest and Me-β-CD cavity are hydrophobic interactions. The formation constant (K) of the complex was calculated and the inclusion complexes had a 1/1 stoichiometry. The 1H NMR data suggested that the guest molecule entered into Me-β-CD from the small port side. Through complexation with Me-β-CD, the water solubility of ofloxacin was significantly increased, this can be used to improve the bioavailability and stability of ofloxacin.