کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5418416 | 1506990 | 2006 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Theoretical evaluation of flavonoids as multipotent agents to combat Alzheimer's disease
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کلمات کلیدی
IHBXanthonesSARBChEMAObutyrylcholinesteraseAβRMSROS - ROSACh - آهAChE - آهیAcetylcholine - استیل کولینAcetylcholinesterase - استیل کولین استرازInhibitor - بازدارندهQSAR - بزرگسال Alzheimer's disease - بیماری آلزایمرDocking - داکتStructure-activity relationship - رابطه ساختار-فعالیتQuantitative structure-activity relationship - رابطه ساختاری و فعالیت کمیFlavonoids - فلاونوئیدهاmonoamine oxidase - مونوآمین اکسیدازها root mean square - میانگین مربع ریشهIntramolecular hydrogen bond - پیوند هیدروژنی داخلیReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی تئوریک و عملی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
As multiple pathogenetic factors, including aggregated amyloid-β peptide and tau protein, excessive transition metals, oxidative stress and reduced acetylcholine level, have been implicated in Alzheimer's disease (AD), multipotent agents aiming at diverse targets are expected to act better than the single-target-aiming counterparts in the fight against AD. Among the potential multipotent agents, natural products, especially flavonoids (including xanthones), have been given much attention. To explore to what extent the desired multiple pharmacological effects can be combined into one flavonoid molecule, we examined the structural requirements of flavonoids (including xanthones) as inhibitors of monoamine oxidase (including isoenzymes A and B), acetylcholinesterase and/or butyrylcholinesterase. In combination with the known structure-activity relationships of flavonoids as reactive oxygen species scavengers and metal chelators, we provide a theoretical evaluation of flavonoids (including xanthones) as multipotent agents to combat AD, which is of great significance to directing the screening of novel AD-modifying drugs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Structure: THEOCHEM - Volume 767, Issues 1â3, 24 August 2006, Pages 3-9
Journal: Journal of Molecular Structure: THEOCHEM - Volume 767, Issues 1â3, 24 August 2006, Pages 3-9
نویسندگان
Hong-Fang Ji, Hong-Yu Zhang,